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This sequential approach may reduce the overall dose requirements of tirzepatide needed to achieve target weight loss

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FIGURE 12 4 Discussion Obesity and diabetes are known to be associated with an increased risk of malignancies such as endometrial cancer, colorectal cancer and postmenopausal breast cancer ( As an emerging treatment for antidiabetic, GLP-1 receptor agonists have satisfactory effect on stable glucose control (Tamborlane et al., 2019), and play a crucial role in weight loss, appetite inhibition and gastric emptying in obese patients ( We first found the differential expression of GLP-1 signaling-related genes in pan-cancer and the genes tended to be positively correlated with each other, suggesting that they may cooperate and function as a whole