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Review criteria Scientific literature was searched for publications reporting switching from one GLP1RA to onceweekly (OW) semaglutide and identified publications were reviewed for relevance

Together, these findings necessitate further investigations to ascertain whether coordinated inhibition of NMDA receptors in GLP-1 receptor neurons modulates neuronal activity beyond canonical feeding regions, such as the mesolimbic dopaminergic reward pathway

Our findings in the ZSF1 obese rat model provide novel mechanistic insight that aligns with these clinical data
