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To view the other articles in this section visit Keywords: arcuate, brain, body weight, diabetes, dorsal vagal complex, energy balance, food intake, glucose, glucose metabolism, GLP1, hypothalamus, NTS, obesity Abbreviations AGRP agoutirelated protein CRH/CRF corticotropin releasing hormone/corticotropin releasing factor GIP gastric inhibitory polypeptide/glucosedependent insulinotropic polypeptide GLP1 glucagonlikepeptide 1 KO knockout MC 4 receptor melanocortin 4 receptor mRNA messenger RNA NPY neuropeptide Y SDA subdiaphragmatic vagal deafferentation Sim1 singleminded 1 TRH thyrotropin releasing hormone 1

Excess weight is associated with venous stasis, particularly in the lower limbs, and obesity is a well-established risk factor for venous thromboembolism

These methods improve signal detection reliability by mitigating random reporting fluctuations and strengthening true safety signals 31

Initially developed for type 2 diabetes and obesity, these drugs also exert central effects relevant to mood regulation, including modulation of reward circuits, appetite control, and attenuation of neuroinflammation [8,16,17]