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Not all patients respond equally to GLP-1 agonist therapy, and identifying optimal candidates requires considering multiple factors, including baseline weight, comorbidities, and individual tolerance profiles

For a long time, the manifestation of depressive symptoms has been also associated with the deficits in neurotrophic factor action in the brain [51], especially highlighting the role of diminished brain-derived neurotrophic factor (BDNF) signaling as important for the pathogenesis of this mental disorder [52]

Interestingly, in a study published in 2024, researchers examined the dynamic, wide-ranging molecular environment in the intact human ileum and found that when plant-based foods with intact cellular structures are consumed, they can increase the delivery of nutrients to the ileum, which subsequently can lead to an increased release of satiety peptides (in particular, PYY)

People with type 2 diabetes who need help with blood sugar control or who also have risk factors for cardiovascular disease are candidates for these medications, according to Diala Alatassi, MD , a double board-certified internal and obesity medicine physician at Endeavor Health in Elmhurst, IL