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Trail registration Study registered in clinicaltrials.org with the identifier NCT05535322.

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Individuals interested in supporting gut microbiome balance and metabolic wellness may consider targeted probiotic supplements

Since most glucose-dependent insulinotropic polypeptide (GIP) receptor: glucagon-like peptide- 1 receptor (GLP- 1) receptor: glucagon receptor triagonists compete in efficacy with bariatric surgery, the success of these agents in preclinical models and clinical trials suggests a bright future for multi-agonists in the treatment of metabolic diseases