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Pharmacologically, signaling studies demonstrate that tirzepatide mimics the actions of native GIP at the GIP receptor but shows bias at the GLP-1 receptor to favor cAMP generation over -arrestin recruitment, coincident with a weaker ability to drive GLP-1 receptor internalization compared with GLP-1

The average age of those 47 patients was 39 years old, with a range of 1571 years old

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