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Nutritionajcn.nutrition.org/article/S0002-9165(25)00240-0/fulltext Ben-Porat, T., Dahan, R., Sherf-Dagan, S., Goldenshluger, A., Kessler, Y., Brzezinski, R

The fascia [connective tissue] isnt as strong, and the skin is dehydrated

Structured recalibration when standard initiation doses are not tolerated: If a patient meets treatment criteria but cannot tolerate the lowest studied initiation level, a lower starting exposure under clinical monitoring may allow incremental receptor engagement while tolerance improves

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