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Specifically, it was highlighted that the GLP-1 deficient mice were markedly more prone to developing seizures and hippocampal degradation [57], thus illustrating GLP-1s importance in preventing these occurrences

391 GLP-1 and GLP-1 analogs exert their effects on food intake and body weight through a myriad of neural substrates, encompassing several hypothalamic nuclei (including the arcuate nucleus of the hypothalamus, periventricular hypothalamus, and lateral hypothalamic area), hindbrain nuclei (such as the parabrachial nucleus and medial nucleus tractus solitarius), the ventral subregion of the hippocampus (vHP), and nuclei embedded within the mesolimbic reward circuitry (including the ventral tegmental area, VTA, and nucleus accumbens, NAc)

When patients discontinue Wegovy, research shows approximately 5070% of lost weight returns within one year because appetite hormones and metabolic rate revert to pre-treatment levels

Comparative effectiveness of GLP-1 receptor agonists on glycemic control and weight outcomes: a systematic review