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But because the landscape around compounded GLP-1 medications has shifted dramatically since the FDA resolved the semaglutide shortage in February 2025, and what was once a straightforward decision now involves regulatory gray areas, legal battles, and quality control questions that most people never expected to navigate

Staying hydrated, eating smaller meals, and maintaining light activity during this peak period can help ease discomfort

Funding This research and manuscript development were funded by Novo Nordisk Pharma Ltd

One technological solution involves the use of a GRAS strain, Lactobacillus paracasei , engineered to express exenatide