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Although leptin inhibits expression of orexigenic NPY/AgPR hypothalamic neurons, while stimulating anorexigenic POMC neurons in ARC (45), its practical therapeutical application in fighting excessive appetite in obese people appears to be unjustified because the majority of obese humans already exhibit high plasma levels of leptin, proportional to the body fat storage, indicating their resistance to circulating leptin (46)

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Published December 6, 2022

Choosing between Semaglutide GLP-1, Ozempic, Wegovy, and Mounjaro depends on individual health goals, specific medical conditions, and how a person responds to treatment