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Dual and triple agonists, including tirzepatide and HM15211, target multiple metabolic pathways and have shown promising results in preclinical AD and PD models [8,54,55]

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Liraglutide's protective effect was further verified in the anterior cruciate ligament (ACL) rat model, in which sub-cutaneous injection of liraglutide 50 g/kg/day for 3 or 6 weeks decreased the number of caspase 3- and CHOP-positive cells in cartilage [35]

(Tesamorelin is also prescribed to treat HIV-associated lipodystrophy, or excess abdominal fat accumulation resulting from antiretroviral therapy