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any adjustments to escalation schedules would be protocol-specific and determined by the trial clinician, as established dose-modification data for retatrutide are not yet available

In 2016, concerns regarding retinopathy associated with GLP-1 were first raised in the Semaglutide Unabated Sustainability in Treatment of T2DM (SUSTAIN) 6 trial with semaglutide [89]

[1] Its mechanism promotes insulin secretion, slows gastric emptying, and reduces appetite, leading to notable improvements in glycaemic control and body weight reduction

We review GLP-1 use as part of our physician-designed screening process, coordinate directly with your prescribing doctor, and build a plan around your health not around a generic checklist