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Abbreviations A: Amyloid AD: Alzheimers disease BBB: Bloodbrain barrier CSF: Cerebrospinal fluid CV: Cardiovascular FDA: US Food and Drug Administration GLP-1: Glucagon-like peptide-1 GLP-1RA: Glucagon-like peptide-1 receptor agonist hs-CRP: High-sensitivity C-reactive protein MACE: Major adverse cardiovascular event MCI: Mild cognitive impairment OD: Once daily OW: Once weekly p-tau: Phosphorylated tau s.c.: subcutaneous T2D: Type 2 diabetes References Scheltens P, De Strooper B, Kivipelto M, Holstege H, Chtelat G, Teunissen CE, et al

Novel GLP-1R Agonists in Neurotherapeutics NLY01 is a pegylated, long-acting GLP-1 receptor agonist designed with a unique peptide sequence that facilitates blood-brain barrier penetration and sustained brain exposure

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