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The FDA ended the shortage February 21, 2025, and clarified on April 1, 2026 that B12 add-ons alone do not automatically qualify a script

While these mechanisms are of high interest in metabolic and neurodegenerative research, the complete safety profile remains under investigation

In interviews and focus groups with employers, virtually every participant that covered these drugs for weight loss purposes highlighted the cost challenges

GLP-1 medications include semaglutide, dulaglutide, and liraglutide, used for type 2 diabetes and weight management Common gastrointestinal effects (nausea, vomiting, diarrhoea) can lead to fluid loss and electrolyte depletion affecting muscle function Maintaining adequate hydration (1.52 litres daily) and dietary electrolyte intake may help prevent cramping Concurrent medications such as diuretics, SGLT2 inhibitors, and statins may contribute to muscle-related symptoms Persistent, severe, or frequent cramps warrant medical review to assess electrolytes, renal function, and exclude other causes Table of Contents What Are GLP-1 Medications and How Do They Work