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[DOI] [PubMed] [Google Scholar] 99.Liu, F., Wu, Q., Dong, Z

Hathaway et al

Short-acting and prolonged-acting GLP-1 receptor agonists (GLP-1RAs) have been developed

The weight-loss effect of GLP-1RAs also benefits NASH improvement, by reducing appetite and increasing energy expenditure to promote weight loss, thereby indirectly ameliorating NASH.206,512 Thus, GLP-1 and its agonists slow down the progression of NASH and may positively impact the reversal of liver fibrosis.513,514 These signaling pathways suggest that GLP-1 and its receptor agonists may influence the progression of NASH through multiple mechanisms, providing several potential therapeutic targets including: FOXO1, a transcription factor that plays a critical role in regulating glucose and lipid metabolism