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Your genetic predisposition to obesitymeasured through variants like FTO rs9939609 and MC4R rs17782313plays a role in how quickly your body resists weight loss after medication stops

The co-expression of GLP-1R, glucokinase, and glucose transporter protein 2 (GLUT-2) in the neurons involved in the control of food intake suggests that these cells may play a role in glucose sensing in the brain [14, 16-19]

While there has been no clear association with certain psychiatric side effects, such as depression or suicidal ideation in research-based 31 or real-world 32 samples, the potential modulation of reward pathways by these drugs necessitates vigilant monitoring in patients with psychiatric histories, particularly in the setting of treatment with a medication that can substantially modulate the response of appetitive neurocircuitry to natural rewards such as food and water
A validated 45-item food frequency questionnaire designed for T2D patients of Han Chinese descent was used to evaluate habitual dietary contents ( Changes in HbA1c and BMI from the baseline to week 12 were reviewed
