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When patients without diabetes mellitus were tested before and after a bariatric procedure, predominantly gastric bypass, half of all patients developed hypoglycaemia

What the Research Shows Recent research on semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) has revealed concerning trends about body composition changes: A 2023 analysis of STEP trial data found that approximately 39% of weight lost on semaglutide was lean body mass 1 Research on tirzepatide showed similar patterns, with 30-40% of total weight loss coming from lean tissue 2 Comparative studies indicate GLP-1 users may lose more muscle than people losing weight through diet and exercise alone 3 For context: if you lose 50 pounds on a GLP-1 medication, 15-20 pounds might be muscle mass

To understand why weight loss takes time, its helpful to understand what retatrutide is doing inside the body

Let your doctor know if you have ever had: Depression Bipolar disorder Thoughts of suicide or a past suicide attempt Also, tell your doctor if you have or have had any of the following: Liver or kidney problems Diabetes or low blood sugar High blood pressure Head injury or seizures Stroke, heart attack, or other heart problems Brain or spine tumors, infections, or blood vessel problems Low sodium levels Alcohol or drug addiction Tell your doctor if you are pregnant or planning to become pregnant