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Consistency relative to your circadian rhythm matters more than consistency relative to wall-clock time

Limitations of Use: Tirzepatide should not be used in combination with other tirzepatide-containing products or any other GLP-1 receptor agonist The safety and efficacy of coadministration with other products for weight loss have not been established Tirzepatide has not been studied in patients with a history of pancreatitis Tirzepatide should not be used in patients with type 1 diabetes mellitus Who should not use tirzepatide

Most providers consider any variance under 5% to be clinically insignificant

The body needs time to adjust to the new receptor activation pattern regardless of prior GLP-1 experience