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We found that although GLP-1 RAs were associated with weight loss and reduced risk of obesity-related comorbidities, MBS was associated with better outcomes, both in terms of durable weight loss and preventing obesity-related comorbidities in the first 2 years following index treatment

Fagerberg B, Edwards S, Halmos T et al (2005) Tesaglitazar, a novel dual peroxisome proliferator-activated receptor alpha/gamma agonist, dose-dependently improves the metabolic abnormalities associated with insulin resistance in a non-diabetic population
At 5 mg/mL, 20 units gives you 1 mg, your week 9-12 dose
The decreased in GFR or albuminuria has been associated with the presence of nonalcoholic steatohepatitis or the severity of fibrosis, whereas improvement in liver histology is associated with improvement in CKD.75 arGLP1 improves insulin levels, regulates autophagy, inhibits hepatic neoglycogenesis, reduces hepatic fat content, plasma liver enzyme levels and hepatic histological improvements have been described with liraglutide and semaglutide.49,76 Likewise, epicardial and perirenal fat are associated with increased cardiorenal risk,77 so that the reduction in ectopic fat43 as demonstrated with the use of arGLP-1 has could be beneficial in CKD
