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Description
GLP-1 receptor agonists directly stimulate GLP-1 receptors in pancreatic islet beta cells and exocrine duct cells

Gastrointestinal effects such as nausea, vomiting, and diarrhea may arise, particularly at the start of treatment or after a dose increase

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These gastrointestinal effects are caused by semaglutide's mechanism: it slows how fast your stomach empties and reduces the signals that tell your brain you're hungry
