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Reinforcing this, in heart failure with preserved ejection fraction, randomized trials such as the STEP-HFpEF program published in the New England Journal of Medicine demonstrated improvements in symptoms and physical limitations, with benefits that could not be fully explained by weight loss alone

The American Diabetes Association Standards of Care and obesity treatment guidelines from organizations like the American Association of Clinical Endocrinology recommend comprehensive obesity management incorporating both pharmacological and behavioral interventions
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The aspiration of stomach contents into the lungs during obstetric anesthesia
