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A direct effect of GLP1-RA on immune cells would obviously require that they express the GLP1-R (Glucagon-like peptide-1 receptor) ( Several reports have suggested that GLP1-R signaling may regulate T cell subsets

Discontinuation of GLP1RAs and tirzepatide typically results in weight regain, deterioration of glycaemic control and the loss of previous improvements in cardiometabolic markers

Chen S, He M, Qin Y, Tian J, Liang Z, Li Y, et al

6,7 Long-term trials evaluating the effects on the immune system may be warranted owing to increased reports of nasopharyngitis, urinary tract infection, and small elevations in white blood cell count