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Very rare in the trials and not consistently linked to retatrutide specifically, but a known concern across the GLP-1 family

47 In patients with overweight or obesity without diabetes, the Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1) trial showed that tirzepatide 15 mg weekly led to a mean body weight reduction of 20.9% after 72 weeks of treatment, compared with 3.1% with placebo

If you require medical care for conditions like diabetes or endocrine disorders, please consult your primary care physician or specialist

For many individuals this may be challenging, so supplementing with whole-foods sources of fiber, including apple pectin, oat fiber, beet fiber, carrot fiber and psyllium husk can help address gaps in dietary fiber intake