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Semaglutide injections begin affecting appetite and blood sugar within hours, but meaningful weight loss typically emerges over 2-4 weeks as your body adjusts to the medication and your dose stabilizes

As GLP-1 receptor agonists, these peptide drugs mimic the incretin hormone GLP-1, enhancing glucose-dependent insulin secretion, suppressing glucagon release, delaying gastric emptying, and reducing appetite [9]

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A qualified provider should evaluate your specific symptoms, medication interactions, and underlying GI function before recommending supplementation