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Both applications, which were filed under the FDAs generic pathway, address all indications of the reference medicines, Mounjaro and Zepbound

When cultured human L-cells were deprived overnight of glucose and serum and then exposed to high glucose, 10% FBS, and -carrageenan (1g/ml) for 10minutes, 1h, and 24h, mRNA expression of proglucagon and secretion of GLP-1 were significantly reduced, compared to control cells not exposed to carrageenan

Exendin-4 is used to clinically improve glucose tolerance in diabetic patients due to its ability to enhance insulin secretion