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Results depend on adherence to the medication, dietary changes, physical activity, and individual metabolism

The STEP program is designed to eluci- date key aspects of the medical manage- ment of obesityacross various races and ethnicities, including whether semaglutide 2.4-mg dosing once weekly is reliably ef- fective (STEP trials 1-5) for patients with and without diabetes, as an adjunct to intensive behavioral therapy plus low-cal- orie diet, and with longer term administra- tion for weight loss maintenance

Cardiovascular effects of GLP-1 RAs have been of great interest since the burden from cardiovascular diseases (CVD) has been unbearably increasing in a diabetic population worldwide, despite strict glycemic control and advanced therapeutic techniques to treat CVD