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In addition, Ex-4 provides neuroprotection against ischemia-induced damage in the hippocampus by downregulating hypoxia-inducible factor-1 and modulating apoptosis through the increased B-cell lymphoma 2 (Bcl-2)/Bcl-2-associated X-protein (Bax) ratio, which is mediated by the GLP-1 receptor [48]

Finally, GLP-1s affect both insulin and glucagon release

All participants had a BMI 27 kg/m, established cardiovascular disease (prior MI, stroke, or peripheral artery disease), but no diabetes, making this the largest trial of a GLP-1RA in a non-diabetic, high-risk cardiovascular cohort

[DOI] [PubMed] [Google Scholar] 397.Bertilsson, G