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The data in Figure 13 summarizes the energetic contributions of GLP-1R residues, along with critical, or more precisely, the hotspot amino acids that contribute to GLP-1R activation and insulin exocytosis
It is worth noting that many of the states with coverage are in the New England and mid-Atlantic region
The drug exhibits a dual elimination pathway through both renal and hepatic routes, making it suitable for use in patients with renal impairment
