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Activation of GLP-1 receptor and GIP receptor alters gastric emptying, intestinal motility, and gut secretions

When to contact your healthcare provider Anyone experiencing severe or persistent semaglutide diarrhea or difficulty staying hydrated should contact a healthcare provider

However, from clinical studies alone, it is difficult to know how much of the benefit is due to direct effects in the joint and how much may be explained by weight loss or broader metabolic changes. That is why we wanted to address a basic mechanistic question first: whether GLP-1 is actually present in the joint environment

45(Suppl 1): S144S174