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37 , 38 have shown that peripheral administration of PYY 3-36 to rodents and humans leads to marked inhibition of food intake

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A recent decision from the Federal Circuit has seriously called into question whether it was proper for Novo Nordisk to list these patents in the Orange Book (discussed below in connection with Wegovy and Rybelsus.) Either way, the injection device patents most likely did not impact the negotiated entry date for the generics since they will all expire before the 343 and 462 patents

Effects of sitagliptin therapy on markers of low-grade inflammation and cell adhesion molecules in patients with type 2 diabetes
