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In the SELECT trial that included over 17,000 patients with obesity and established CV disease, but without diabetes, weekly s.c
30, 2026 An earlier version of this story mistakenly said that the drug tirzepatide blocks a hormone called GIP
While most GI side effects (nausea, vomiting and diarrhoea) caused by GLP-1RAs are mild to moderate and short-lived [5, 6, 50], they can be minimised by recommending simple measures such as eating smaller meals, stopping eating as soon as the patient feels full, and injecting at mealtimes
Quantifying ligand bias at seven-transmembrane receptors
