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Least-squares mean standard error changes from baseline to final heart rate were + 2.7 0.2, + 1.0 0.3, and + 3.0 0.4 bpm with exenatide QW, exenatide BID, and liraglutide, respectively, and 0.8 0.2 bpm with non-GLP-1RAs

The authors show that GIPR activation enhances entry of GLP-1R agonists into the brain, and this process depends on oligodendrocyte GIPR signaling

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