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The proposed mechanism of action of these peptides is that they enter the hind-brain from the peripheral bloodstream, and interact directly with GLP-1 receptors in the brain - possibly the parabrachial nucleus ( 2 Materials and methods 2.1 Materials Peptides exendin-4 (exenatide) and semaglutide were obtained from Bachem AG, Bubendorf, Switzerland

The prevention of the glucagon rise might improve the beneficial effects of the combination therapy to enhance glucose control and may support this combination therapy in clinical practice [81]

2 Among the people who stayed on the medication and reached the full dose, average weight loss reached 16.6%

Zhang Z, Zhang Q, Tan Y, et al