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Subgroups, CV risk score and outcomes In the post hoc analysis of two subgroups (subjects with metformin use and subjects without metformin use at baseline [metformin/no-metformin]), patient-level data from the SUSTAIN 6 and PIONEER 6 trials were pooled: semaglutide (subcutaneous and oral) vs placebo

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Changs findings suggest that EX-4 inhibited LPS-induced iNOS expression at protein level, but not at transcriptional level, of iNOS gene via a cAMP/PKA dependent mechanism (71)