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However, this task is hampered by suboptimal gastrointestinal protein absorption

Renal Protection: Through tubulointerstitial fibrosis, podocyte damage, and glomerular endothelial dysfunction, oxidative stress and chronic inflammation also contribute to the progression of diabetic kidney disease

359 The inhibition of MELK expression significantly downregulates the expression of the ferroptosis-related genes PTGS2 and SLC39A14 and significantly reduces the expression of the lipid peroxidation marker 4-HNE and the oxidative stress marker MPO, thereby inhibiting macrophage infiltration and M1 polarization, reducing the secretion of proinflammatory factors, and alleviating intestinal tissue damage and intestinal inflammation