fda compounding semaglutide crackdown news today The FDA's GLP-1 Continues: What to Know FDA to Restrict Ingredients Used

A1C reduction results with Rybelsus Research shows that Rybelsus reduced A1C by 1.2% over 26 weeks

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YES, and translation to the clinic is on the way Complete masterclass by @h_sokol #DDW2025 Modify gut microbiota impacts disease severity In mice models In humans (FMT) Faecal microbiota from patients with IBD exacerbate colitis in mice Altered gut microbiota in IBD bacteria and fungi and viruses with decreased diversity and change in composition The alterations in the gut microbiome precede development of CD by several years and occur in the absence of inflammation in the gastrointestinal tract (GEM study) Therapeutic strategy Hit the bad guys: Antibiotics _ risk of antibiotic resistance and toxicity Phages _ advantages as more targeted Boost the good guys: FMT has some effect but impossible to standardise

headache was the most common side effect, and exploratory breast-milk measures suggested rapid clearance Pre-registered experiment gave 78 healthy volunteers inert air framed as nitrous oxide Context alone increased altered states, ego dissolution, dissociation, and side effects, despite no active drug Suggestibility and absorption helped predict who was most responsive, sharpening how we think about set, setting, placebo, and nocebo effects - Two randomised trials tested oral prolonged-release ketamine: a Phase 1 crossover study (n=26) and a Phase 2 placebo-controlled TRD trial (n=122) The tablet caused far less dissociation and cardiovascular change than intranasal esketamine But it missed the main day-21 depression endpoint, showing that better tolerability does not automatically mean better efficacy ;: June brought a striking early GH001 signal in postpartum depression, a reminder that context can produce psychedelic-like effects without a drug, and a ketamine formulation trial where better tolerability did not translate into a clear antidepressant win