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Description
In this experiment, the high protein diet can promote intestinal secretion of GLP-1, improve FGF21 resistance, upregulate LKB1 to activate the AMPK pathway, downregulate the expression of SERBP-1c mRNA and protein in the liver, and ultimately inhibit liver lipid synthesis [50]
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The second part of this study was conducted on C57BL/6J and GLP-1 receptor KO mice
While the candidate achieved pharmacokinetic objectives, the program was discontinued due to a single case of potential liver injury among over 1,400 trial participants
