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therefore, WD-fed MC4R-KO mice are advantageous as a rodent MASH model owing to their ability to be established quickly

* Potent high-intensity statin * Strong LDL-lowering effect * Lower CYP450 metabolism compared with some other statins * Major adverse effect tested: myopathy/rhabdomyolysis Rosuvastatin: Mechanism, Indications, and Side Effects Rosuvastatin Class * HMG-CoA reductase inhibitor (statin) Used to lower cholesterol and reduce cardiovascular risk

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These approaches are grounded in nutritional science and behavioural research, and are consistent with guidance from UK bariatric dietetic practice