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doi:10.1016/j.annonc.2026.04.013

But if you are overweight or have mild obesity without associated diseases, the risks may or may not outweigh the benefits

They are pushing patients and doctors toward the drugs specifically approved for that purpose, like Wegovy and Zepbound, which have their own set of formidable hurdles

In conclusion, GLP-1R signals exclusively via G s proteins (G s selective) and does not undergo significant desensitization, in contrast to GIPR that interacts with both G s proteins and arrestins equally robustly (non-selective, pleiotropic balanced receptor) and is severely desensitized in vivo