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M., Brunelle C

Patients who experienced the greatest hunger reduction achieved weight losses exceeding 15%, while those with modest appetite changes averaged 58% loss

However, given the large and growing body of preclinical literature highlighting mechanisms outside of body weight contributing to sex differences in effects of GLP-1R agonism (eg, interactions with estrogen), the case for meaningful and potentially clinically relevant differences remains, if not strong, then at least certainly warranting careful attention to sex as an important variable in GLP-1 system research

The medication helps control your appetite and cravings, but lasting success comes from building healthy habits