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Importantly, the largest reductions in BMI were observed in the southern United States, which also reported the highest rates of GLP-1 RA dispensing claims (Rader et al., 2024), a geographic concordance that is consistent with a causal contribution of these pharmacotherapies to the observed population-level BMI decline

This creates a natural pathway for weight managementwithout relying solely on medications

Familial PD genes (Parkin [ PRKN , also known as PARK2 ] and PINK1 ) implicate impaired mitophagy in disease progression (63), fluorodeoxyglucose PET (FDG-PET) studies show consistent cerebral glucose hypometabolism (64), and hypothalamic dysfunction has been linked to ALS and HD (65)