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If side effects are not understood by the patient, they can undermine the success of the medication
The primary contraindication is a personal or family history of Medullary Thyroid Carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

Xing C, Yin Y, Chang R, Gong X, He X, Xie Z (2007) Effects of insulin-like growth factor 1 on synaptic excitability in cultured rat hippocampal neurons

Key finding from recent research highlights the risks associated with GLP-1 therapy: Despite a less than 1% overall risk, the findings suggest a consistent elevated risk in comparison to those not on these medications
