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Description
Clinically, this matters because chronic migraine is not defined by one dramatic headache
While some patients may perceive mood changes during tirzepatide therapy, current clinical evidence does not establish a direct link between tirzepatide and anger or irritability specifically
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The STEP UP trial, published in The Lancet Diabetes & Endocrinology in September 2025, showed 18.7% average weight loss at 72 weeks compared to 15.6% at the standard 2.4 mg dose
