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AEs: Adverse events, BMI: Body mass index, GI: Gastrointestinal, HbA1c: Glycated haemoglobin, PK/PD: Pharmacokinetics/Pharmacodynamics, RCT: Randomised controlled trial, T2DM: Type 2 diabetes mellitus, wk: Weeks Weight reduction Across all studies, retatrutide produced consistent, dose-dependent reductions in body weight, with the magnitude of effect increasing proportionally to dose and study duration [Table 2]

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