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One of the most severe is gastroparesis

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Romosozumab is a monoclonal antibody against osteostatin that not only inhibits the activity of osteostatin (sclerostin) and upregulates the Wnt signaling pathway but also blocks the RANKL pathway, antagonizes its negative regulation of bone metabolism, promotes bone formation, and inhibits bone resorption ( Recent preclinical and clinical studies have shown that gut hormones may have a profound effect on bone remodeling and, ultimately, bone structure and strength (Figure 4)