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In accordance with the 2018 NIA-AA Research Framework criteria [25] or the new 2023 NIA-AA revised criteria for AD [26], the incorporation of biomarkers is necessary in clinical practice

To test this, we employed a mouse model with a double Glp-1r and Gipr KO and a pharmacological approach using the specific GLP-1R antagonist exendin-3

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The most evidence-supported approach starts with a consistent skincare routine, adds topical retinoids as the primary active treatment, and incorporates benzoyl peroxide for antimicrobial activity (Leyden et al., 2017)