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Pasireotide drastically inhibited GLP-1 secretion induced by Gs-coupled receptor stimulation through SSTR5-Gi-dependent inhibition of cAMP levels, suggesting that the main pathway was completely blocked

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GLP-1s vs TRT: Revolutionary New Data on Male Hormones Men with obesity and low testosterone have faced an impossible trade-off: TRT improves symptomsbut kills fertility and ignores root causes GLP-1s promote weight loss, but their hormonal impact was unclear until now
