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Female patients of child bearing age should be counselled about contraception because of how AOM reduces gastric emptying and can reduce the efficacy of oral contraception on initiation and uptitration

This insight helps your provider predict whether you'll respond optimally to semaglutide alone or whether a different GLP-1 compound or dual-peptide approach (like GLP-Squared) may deliver better outcomes while accounting for methotrexate's metabolic effects

The protocol and datasets used and/or analysed in this study will be available from the corresponding author on reasonable request

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