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With teen smokers in particular, researchers saw heightened responses in brain regions rich in the neurotransmitter dopamine, a chemical that modulates pleasure and reward centers and helps regulate emotions

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Miles Davis on stage with a cigarette in one hand and a trumpet in the other

Once BD has manifested, the neuroprogression hypothesis in BD postulates that the recurrent mood swings might lead to growing damage in both neurons and glia, impairing the integrity of neuronal circuits and reinforce brain vulnerability to emerging mood episodes in the future (35), and finally leading to neurodegeneration (36)