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This survey, which assesses smoking cessation treatment in Japan, was developed to diagnose nicotine dependence from a psychiatric perspective in accordance with the WHO International Classification of Diseases, 10th Edition, and the revised 3rd and 4th editions of the American Psychiatric Associations Guide to the Classification and Diagnosis of Psychiatric Disorders

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Decades-old research supports its mechanistic actions, including a 1992 review published in Progress in Neuropsychopharmacology and Biological Psychiatry, which concluded that nicotine improved attention in a wide variety of tasks, and supported immediate and longer term memory in healthy volunteers